Electron-Deficient C2 Fragments Cycloadditions Involving Azomethines, Nitrones, Nitrile Oxides, and Dienes

Electron-Deficient C2 Fragments (Cycloadditions Involving Azomethines, Nitrones, Nitrile Oxides, and Dienes) 

Electron-poor C-C fragments are readily accessible through immobilization of maleimides or acrylesters and acrylamides onto various polymeric supports. They have been used in [2 -1- 3]- and [2 -1- 4]-cycloadditions. 

Uncatalyzed Diels-Alder reactions and [2 + 3]-heterodipolar cycloadditions can be performed on a variety of acrylic or maleimide-based resins. One simple method is to link an acrylic residue to a polymeric support via an ester or an amide linkage. 

Azomethine ylides allow access to the pyrrolidine nucleus. 

Alanine methyl ester (92 mg, 0.66 mmol) in toluene (2 mb) was added to a slurry of maleimide supported on trityl resin (200 mg, ca. 0.22 mmol), 

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