Electrical Transduction of DNA Hybridization

The use of enzyme labels to generate electrical signals also offers great promise for ultrasensitive electrochemical detection of DNA hybridization. This can be accomplished by combining the hybridization step with an electrochemical measurement of the product of the enzymatic reaction. The 

Increased attention has been given to new indicator-free electrochemical detection schemes that greatly simplify the sensing protocol. Such direct, label- 

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Kawde, A. and Wang, J. (2004) Amplified electrical transduction of DNA hybridization based on polymeric beads loaded with multiple gold nanoparticle tags. Electroanalysis, 16, 101-117. 

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