Elderly patients enalapril

Weisser K, Schloos J, Jakob S, Muhlberg W, Platt D, MutscWer E. The influence of hydrochlorothiazide on the pharmacokinetics of enalapril in elderly patients. EurJ Clin Pharmacol... 

Verza M, Cacciapuoti F, Spiezia R, D Avino M, Arpino G, D Errico S, Sepe J, Varricchio M. Effects of the angiotensin converting enzyme inhibitor enalapril compared with diuretic therapy in elderly hypertensive patients. J Hyper tens 1988 6(suppl 1) S97-S99. 

In one study, sulindac 200 mg twice daily given to patients taking capto-pril 100 to 200 mg twice daily caused only a small rise in blood pressure (from 132/92 to 137/95 mmHg). Sulindac 150 mg twice daily did not attenuate the blood pressure response to captopril when it was substituted for ibuprofen in an elderly woman. Similarly, sulindac 200 mg twice daily did not blunt the antihypertensive effect of enalapril in 9 patients with hypertension. Two studies in black women also found that sulindac 200 mg twice daily for one month did not alter the antihypertensive effect of fosinopril 10 to 40 mg daily or lisinopril 10 to 40 mg daily (given with hydrochlorothiazide 25 mg daily). - ... 

Hyperkalaemia, resulting in marked bradycardia, was attributed to the use of loxoprofen in an elderly woman taking imidapril. A 77-year-old woman with mild hypertension and normal renal function taking enalapril 2.5 mg daily arrested and died 5 days after starting treatment with rofeeoxib for leg pain. Her potassium was found to be 8.8 mmol/L. Infection and dehydration could have contributed to the hyperkalaemia in this patient. ... 

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