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Elastic protein-based machines

Visual Observation of Elastic Protein-based Machines at Work... [Pg.147]

Constructing Macroscopic Elastic Protein-based Machines... [Pg.148]

Due to the struggle to survive under circumstances of limited food supply, organisms evolve to use the most efficient mechanism available to their composition. The most efficient mechanism available to the proteins that sustain Life would seem to be the apolar-polar repulsive free energy of hydration as observed for the inverse temperature transitions for hydrophobic association. The efficiency of designed elastic-contractile protein-based machines and a number of additional properties make designed protein-based materials of substantial promise for the marketplace of the future. [Pg.62]

V in Table 5.5 with 0,2,3,4, and 5 F residues per 30-mer exhibits a systematic nonlinear increase in steepness, that is, in positive cooperativity, and an associated nonlinear increased pKa shift, as plotted in Figure 5.34. The energy required to convert from the COOH state to the COO" state systematically in a supralinear way becomes less and less, as more Phe residues replace Val residues. The energy required to convert from the hydrophobically dissociated state of COO" to the hydrophobically associated (contracted) state of COOH becomes less, as the model protein becomes more hydro-phobic. The elastic-contractile protein-based machine becomes more efficient as it becomes more hydrophobic. The cooperativity of Model Protein iv with a Hill coefficient of 2.6 is similar... [Pg.198]

On the Relevance of Hydrophobic and Elastic Consilient Mechanisms to Biology s Protein-based Machines... [Pg.331]

Accordingly, the perspectives in Chapter 5, developed on elastic-contractile protein-based polymers, introduce new concepts into the functional description of biology s protein-based machines. As with the introductory comments in Chapter 7, the footnote relevant to reactions toward new concepts in science is repeated here in footnote form. ... [Pg.332]

This chapter discusses key protein-based machines of biology to demonstrate the relevance of the hydrophobic and elastic consilient mechanisms. The objective in this chapter, therefore, is to investigate selected examples of biology s protein-based machines and to look at the molecular level for a coherence of phenomena with the designed elastic model... [Pg.332]

The second point addresses the nature of elastic force development in relation to imder-standing efficient energy conversion. If the energy required for chain deformation during elastic force development becomes lost to other parts of the protein and to the surrounding water, then so too is efficient energy conversion lost. In other words, elastomeric force development on deformation in a protein-based machine followed by marked hysteresis on relaxation necessarily denotes an inefficient protein-based machine. [Pg.342]

The development of force under conditions of fixed length, as in an isometric contraction, involves the elastic deformation of a chain or chains within the protein-based machine. On relaxation, ideal elastic elements return the total energy of deformation to the protein-based machine for the performance of mechanical work. Thus, the approach toward high efficiency for the function of a protein-based linear motor, or even for the RIP domain movement in Complex III, depends on how nearly the extension of an elastomeric chain segment approaches ideal elasticity. [Pg.344]


See other pages where Elastic protein-based machines is mentioned: [Pg.169]    [Pg.169]    [Pg.127]    [Pg.22]    [Pg.26]    [Pg.31]    [Pg.49]    [Pg.51]    [Pg.84]    [Pg.95]    [Pg.102]    [Pg.103]    [Pg.107]    [Pg.120]    [Pg.120]    [Pg.128]    [Pg.168]    [Pg.210]    [Pg.219]    [Pg.224]    [Pg.254]    [Pg.264]    [Pg.330]    [Pg.331]    [Pg.332]    [Pg.336]    [Pg.342]    [Pg.344]   


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