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Efflux pumps inhibiting polymers

Limited local inhibition of these transporters by using polymeric inhibitors could reduce such systemic risks and side effects. Efflux pump modulating polymers and surfactants mentioned in this review have been distinguished between nonionic, ionic and thiolated polymers. [Pg.128]

Polymers may enhance drug permeability if they can (i) open the intercellular spaces, (ii) increase the fluidity of the lipid membrane, (iii) inhibit or evade efflux pumps, (iv) inhibit or evade enzymatic activity, and/or (v) facilitate the access to the cell by an alternative mechanism. [Pg.333]


See other pages where Efflux pumps inhibiting polymers is mentioned: [Pg.137]    [Pg.147]    [Pg.137]    [Pg.147]    [Pg.147]    [Pg.95]    [Pg.434]    [Pg.76]    [Pg.236]    [Pg.237]    [Pg.506]    [Pg.428]    [Pg.334]    [Pg.335]    [Pg.335]    [Pg.46]    [Pg.236]    [Pg.237]   
See also in sourсe #XX -- [ Pg.147 ]




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