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Wyeth ( 16 billion in sales). Formerly known as American Home Products, this company headquartered in Madison, New Jersey, makes many well-known OTC drugs such as Robitussin and Advil. The company first used machines to mass-produce tablet pills in 1872 and supplied the polio vaccine for early trials in the 1950s. It produced a diet drug called fenfluramine that when combined with other drugs into a form known as fen-phen caused health problems and was withdrawn from the market. It makes Premarin and Prem-pro for estrogen replacement, Effexor for depression and anxiety disorders, Ativan for anxiety and insomnia, and Enbrel for arthritis. 

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