Effects of Exposure to JP-8 and Kerosene in Experimental Animals

The work of Mattie et al. suggests that continuous exposure of rats and mice to JP-8 vapor at up to 1,000 mg/m3 for 90 days had no effect on the rodent cardiovascular system. Rats and dogs repeatedly exposed to kerosene at concentrations up to 100 mg/m3 did not show any treatment-related effects. 

The subcommittee recommends that cardiovascular toxicity be evaluated in experimental animals exposed to JP-8 vapors and mixtures of vapors and aerosols by the inhalation route. 

Carpenter, C.P., D.L. Geary Jr., R.C. Myers, D.J. Nachreiner, L.J. Sullivan, and J.M. King. 1976. Petroleum hydrocarbon toxicity studies. XI. Animal and human response to vapors of deodorized kerosene. Toxicol Appl. Pharmacol. 36 (3) 443-456. 

Chenoweth. 1948. Studies on hydrocarbon-epinephrine induced ventricular fibrillation. J. Pharmacol. Exp. Ther. 94 12-18. 

Gibson, R.L., S. Shanklin, and R.L. Warner. 2001a. Health effects comparisons. Pp. 125-129 in JP-8 Final Risk Assessment Report. The Institute of Environmental and Human Health (TIEHH), Lubbock, TX. August 2001. 

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