Effects of Exposure to BPA

Adverse health effects of exposure to BPA have been reported at a range of doses including a substantial literature on effects at doses well below the reference dose of 50 pg/kg body weight/day deemed safe by the USEPA. Most of the data, however, are based on animal model studies. A detailed discussion of these effects and the possible mechanisms of toxicity involved are beyond the scope of this chapter. However, the major effects are summarized in Table 7.4. The reader is directed to references, recent books (Vaughn, 2010) and reports (Bergman et al., 2013 Wargo, 2008) on the topic for detailed information. 

The available human exposure studies clearly shows the perturbation of reproductive function by BPA (Li et al., 2010a Meeker and Ferguson, 2012) and prenatal 

TABLE 7.4 A Summary of Biological Effects of Exposure to BPA at Low Doses 

System affected Adverse effect reported References 

Male reproductive Reduced sperm count vom Saal et al. (1998) 

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