Effective dose equivalent function relationship

The effects of different model parameters on the plasma concentration versus time relationship can be demonstrated by mathematical analysis of the previous equations, or by graphical representation of a change in one or more of the variables. Equation (10.95) indicates that the plasma concentration (Cp is proportional to the dose (Av) inversely proportional to the volume of distribution (V)- Thus an increase in Aw or a decrease in Fboth yield an equivalent increase in Cp as illustrated in Figure 10.20. Note that the general shape of the curve, or more specifically the slope of the line for ln(Cp versus t, is not a function of Av or V. Equations (10.98) and (10.99) show that the... 

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