Effect time course

DoTS classification (BMJ 2003 327 1222-5) Dose-relation hypersusceptibility effect Time-course intermediate... 

Adverse effect Lactic acidosis due to biguanides Dose-relation toxic effect Time-course time-independent Susceptibility factors genetic (slow phenformin metabolizers) age disease (impaired liver, kidney, or cardiac function, alcoholism)... 

DoTS classification Dose-relation collateral effect Time-course delayed... 

Dose-relation toxic effect Time-course intermediate or delayed Susceptibility factors high doses or intravenous administration psychiatric disorders dehydration postpartum... 

Nonlethal Toxicity (include species and strain, number of animals, exposure concentrations and durations, critical effects, time-course data) (The order of animals shown should be used. If no data are available for a species, the number should be used for the next species discussed.)... 

Dose-relation toxic effect Time-course time-independent... 

Dose-relation hypersusceptibility effect Time-course immediate... 

One method for establishing the dose cycle to be used for constructing the concentration-response curve of a particular twitch inhibitor is to perform a time-course experiment with a single dose of the inhibitor. This dose is added to the tissue in the organ bath and then at particnlar times after this addition (e.g., 5,10,15, 30, 45, 60, 90,120, and 150 min), the tissue is stimulated for 2 min and the height of resulting contractions recorded. The time taken for inhibition of the electrically evoked contractions to reach a platean is indicative of the time required for the test dose to produce its full effect. Time-course experiments can be repeated with other doses of the same twitch inhibitor. For some cannabinoids it can take more than 60 min for the response to a particnlar dose to develop fully in the vas deferens (14). Typical dose cycles for some commonly used cannabinoids are shown in Table 3. 

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