Effect of amino acid sequence

R. Tyler-Cross and V. Schirch, Effects of amino acid sequence, buffers and ionic strength on the rate and mechanism of deamidation of asparagine residues in small peptides, J. Biol. Chem, 266, 22549 (1991). 

The effect of amino acid sequence on peptide partitioning was discussed... 

Hong, Y., Legge, R.L., Zhang, S., and Chen, P. "Effect of amino acid sequence and pH on nanofiber formation of self-assembling peptides EAK16-II and EAK16-IV". Biomacromolecules 4(5), 1433-1442 (2003). 

Table 10.1 Overview of some polypeptide growth factors. Many can be grouped into families on the basis of amino acid sequence homology, or the cell types affected. Most growth factors are produced by more than one cell type and display endocrine, paracrine or autocrine effects on target cells by interacting with specific cell surface receptors...

Following an introductory section on the historical background that has led to the development of RPC techniques as practiced today, the principles and theory of RPC will be discussed, incorporating the role of amino acid sequence and hierarchical structural effects that determine the outcome of the interaction of a peptide(s) with various types of nonpolar chromatographic surfaces. Subsequently, the influence of operating parameters such as the effects of different (1) surface morphologies or chemistries of nonpolar sorbents (2) concentrations of organic solvents, salts, or other mobile-phase additives (3) pH conditions or... 

In addition to comparison of amino acid and nucleotide sequences of a-lactalbumin, and their rates of change as molecular clocks, a considerable amount of comparative information has accumulated on the three-dimensional structure of these proteins their physical properties in soludon effects of amino acid subsdtudons, in both genetic and cloned variants and their funcdons and immunological properties. In assessing this informadon it is important not to lose sight of the known paleontological informadon on the origin and evolution of mammals. 

Caplan MR, Schwartzfarb EM, Zhang S, Kamm RD, Lauffenburger DA (2002) Effects of systematic variation of amino acid sequence on the mechanical properties of a self-assembling, oligopeptide biomaterial. J Biomater Sci Polym Ed 13 225-236. doi 10.1163/ 156856202320176493... 

As pointed out by Matta [20], a threshold of dissimilarity is assumed between the members of a molecular set for the construction of a QSAR model. Similarity is commonly quantified on the basis of amino acid sequence matching [76], mismatching of 2-dimentional chemical graphs [8], on 3-D molecular skeleton superpositions [77], and on point-by-point comparison of electron density—pioneered by Carbo [78-81] or of the molecular electrostatic potential [82-94]. Through relationships (5) and (6) in Ref. [20], a similarity of p r) necessarily leads to the similarity of all other ground-state properties, and hence the most fundamental molecular comparisons are those effected at the electron density level. 

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