EDT, 1,2-Ethanedithiol

The kinetics and mechanism of rhenium-catalyzed desulfurization of thiiranes was studied experimentally and by means of computation <2006IC5351>. The oxorhenium dimer MeReO(edt)2 (X), where edt= 1,2-ethanedithiolate, was found to catalyze the transfer of S from thiiranes to triarylphosphines and triarylarsines. In the case of phosphines, catalysis was less effective because they converted the dimer catalyst rapidly to MeReO(edt)PAr3, a less effective catalyst. The rate law for AsArs, which did not transform the catalyst, was v = [thiirane][X] with k = 5.581 mol s at 25°C in CDCI3, for X = cyclohexene sulfide. The value of was 10.0 0.9kcalmoP, while AY was —21 3calK moP. The proposed mechanism is shown in Scheme 6. 

The reaction between Co(PPh3)3Br and Na2cdt (edt = 1,2-ethanedithiol) afforded [Co7(/t4 S)3( 3-S)3(PPh3)6Br], 472 (Figure 96), in which the cobalt atoms are at lower oxidation levels as compared to closely related complexes reported already in COMC (1995) (see (i) for Cos). 

TPA trifluoroaceticacid, TES triethylsilane, EDT 1,2-ethanedithiol, DTT dithiothreitol, DOD T2,2 (Ethylenedioxy) diethanethiol... 

Peptide synthesis reagents such as diisopropylcarbodiimide (DIC), benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBOP), bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBroP), 2-(lH-benzotriazole-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate (HBTU), 1-hydroxybenzotriazole (FlOBt), piperidine, A-methylmorpholine (NMM), trifluoroacetic acid (TEA), triisopropylsilane (TIS), A -diisopropylethylamine (DIPEA, DIEA), l,8-diazabicyclo[5.4.0]undec-7-ene (DBU), 1,2-ethanedithiol (EDT), and 4-dimethylaminopyridine (DMAP) may be obtained from Sigma-Aldrich, Chemlmpex, and Novabiochem. 

Peptide synthesis reagents and materials Use NovaSyn TGR resin (Novabiochem) for C-terminal amide synthesis and Fmoc amino acid monomers (Novabiochem) including Fmoc-Arg(Pbf)-OH, Fmoc-Asn(Trt)-OH, Fmoc-Cys(Trt)-OH, Fmoc-Gln(Trt)-OH, Finoc-Glu(OfBu)-OH, Fmoc-His(Trt)-OH, Fmoc-Lys(Boc)-OH, and Fmoc-Trp(Boc)-OH. Other peptide synthesis reagents are as for PNA (above) with the addition of 1,2-ethanedithiol (EDT, >98%, Fluka). A Phenomenex Jupiter C-18 column (analytical and semi-preparative) may be used for reversed-phase HPLC. 

The diamagnetic sulfido complex AsPh4[TcS(edt)2] >(Tc=S) at 520 cm-1] is formed from the reaction of [TcC16]2 with 1,2-ethanedithiol and [TcSCl2 HB(pz)3 ] from the oxo complex by S atom transfer from B2S3 (379,549). The [TcS]3+ core is less stable than [TcO]3+ and readily undergoes replacement of the sulfido ligand by oxo in solution and under aerobic conditions. 

Indium(III) complexes of dianionic sulfur ligands are mostly those derived from toluene-3,4-dithiolate (TDT ), l,2-dicyanoethylene-l,2-dithiolate (MNT ), 1,2-ethanedithiol (EDT ), or l,l-dicyanoethylene-2,2-dithiolate (i-MNT ). Various adducts (e.g., four-coordinate [In(MNT)2], five-coordinate [XIn( -MNT)2] (X = C1, Br, or I), or six-coordinate [In( -MNT)3] ) have been reported. " ... 

With the exception of lysine, the process of trityl group removal from the side-chains of these amino acids is an equilibrium. Consequently, in order to push the equilibrium in the desired direction, a cation scavenger such as triisopropylsilane (TIS) or 1,2-ethanedithiol (EDT) is added to the cleavage mixture, or the reaction is conducted in a continuous-flow manner. With the latter approach, the progress of the reaction can be monitored at 400-500 nm and by following the decrease in optical density with time of the reaction effluent. 

The dithia-analog of EDOS, 3,4-ethylenedithioselenophene (EDTS) could be prepared by transetherification of 3,4-dimethoxyselenophene with 1, 2-ethanedithiol. The homopolymer, PEDTS, was synthesized electrochemi-cally and by solid-state oxidative polymerization. PEDTS has a significantly... 

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