Edmundson wheels

Schiffer, M., and Edmundson, A, B. Use of helical wheels to represent the structures of proteins and to identify segments with helical potential. Biophys. J. 7, 121-135 (1967). 

Fig. 12. Representation of the carboxyl terminal (residues 14-31) moiety of human /3-endorphin (peptide 6, Table 2) on an Edmundson helical wheel [54]. If /3-endorphin chromatographed at any time with a carboxyl terminal amphipathic a-helical structure, the segments incorporating (Leu-14)-(Phe-18)-(Ala-21)-(Asn-15) and (Val-15)-(Ile-22)-(Ala-26) would represent the sites most likely to interact with a reversed phase support.

Approaches considering stereochemical aspects are the wheel representation of helical regions by Schiffer and Edmundson and a secondary structure prediction heme... 

Schiffer and Edmundson observed that nonpolar residues within a helical i on of a protein show a significant tendency to form nonpolar clusters. This finding vras illustrated by means of a so-called helical wheel (Fig. 5). 

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