Edema, premenstrual

Although pyridoxine (vitamin Be) is used commonly as a treatment for PMS in doses of 50-100 mg/day, there is no evidence that women have a premenstrual pyridoxine deficiency. Pyridoxine has been reported to reduce the severity of premenstrual depression, fatigue, irritability, headache, and edema, but controlled studies have provided little support for its efficacy in PMS. After a metaanalysis of nine published studies with pyridoxine, the authors suggested that doses of 50-100 mg/day pyridoxine may be beneficial in relieving premenstrual symptoms despite the lack of randomized, controlled studies. Pyridoxine has been reported to cause peripheral neuropathy in excessive doses (e.g., 2000-6000 mg/day), and a reversible peripheral neuropathy has occurred with daily dosages of 200 mg. - ... 

For premenstrual edema, add Sclerotium Poriae Cocos (FuLing) and Rhizoma Alismatis (ZeXie). 

It is a thiazide diuretic useful in the management of edema associated with cardiac failure, hepatic cirrhosis, premenstrual tension, and steroid administration. 

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