Eco-Efficiency Benefits

To complete the environmental comparison of routes 3 and 4, in-house methodology for comparing technologies and processes was undertaken. In this assess- 

This work was carried out by a highly skilled and motivated team of people from all areas of GSK, and 1 would hke to thank aU of them for their commitment and dedication to the project. In addition 1 would like to acknowledge the assistance from the staff of Novasep (France) and Chiral Technologies Europe for their contributions and very helpful discussions to the development of the MCC process. It is to all of these people that this chapter is dedicated. 

753-768, and references cited therein. Szelenyi, I., Geisslinger, G., Polymero-poulos, E., Paul, W., Herbst, M., and Brune, K. (1998) Drug News Perspect., 11 (3), 139-160, and references cited therein. Gurjar, M.K. (2007) J. Ind. Med. Assoc., 105,177-178. 

For more information on the role of Process Chemistry and factors that a Process Chemistry team consider when designing a synthetic route see Zhang, T.Y. (2006) Chem. Rev., 106, 2583-2595 and Butters, M., Catterick, D., Craig, A., Curzons, A., Dale, D., Gillmore, A., Green, S.P., Marziano, I., Sherlock, ).-P., and White, W. (2006) Chem. Rev., 106, 3002-3025. 

22 Private communication see also Rouhi, A.M. (2003) Chem. Eng. News, 81 (18), 45-55. 

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