Echinacea augustifolia

Echinolone American coneflower roots Echinacea augustifolia DC. Tenebrto molltor pupae Injection 0.97 pg 109... 

Root extracts of the American coneflower, Echinacea augustifolia DC., also exhibited juvenoid activity [114] ether extracts showed high morphogenic activity on T. molitor pupae but none was observed on fifth instar nymphs of O. fasciatus (500 ig of extract). The active principle in the oil was identified as ( )-10-hydroxy-4,10-dimethy 1-4,11-dodecadien-2-one or echinolone (Fig. (6)) [109]. However, chemically synthesized echinolone was not active in the standard T. molitor pupal bioassay [115]. The authors of this report acknowledge that this may be due to a failure to synthesize the proper compound. However, the spectral data is consistent with that reported. They were also unable to isolate echinolone from the roots of E. augustifolia. The chemical data for echinolone are summarized in Appendix III, Table 12 and the synthesis of racemic echinolone has been reported [115, 116]. 

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