Ecdysone crystal structure

Publication of the crystal structure of the Hdiothis viresence EcR (HvEcR) LBD heterodimerized with LBD of H. viresence ultraspiracle protein (HvUSP) with and without ponasterone A (phytoecdysteroid) or a BAH ecdysone agonist provided a more realistic conformation of the HvEcR LBD and the ligands in the LBD [21]. The most surprising result was that ponasterone A co-crystallized in the HvEcR LBD in an orientation opposite to that predicted by the CoMEA, 4D-QSAR and... 

---