Ecdysone antagonist

Mu X, LeBlanc GA. 2004. Synergistic interaction of endocrine-disrupting chemicals model development using an ecdysone receptor antagonist and a hormone synthesis inhibitor. Environ Toxicol Chem 23 1085-1091. 

Obviously, ecdysone or analogues that have similar or antagonistic modes of action could disturb the normal development of the insects and so can be used as insecticides. Inhibitors or inducers of the ecdysone biosynthesis may also be developed as insecticides. 

Adenyl cyclase has been shown to be stimulated by -ecdysone (81) in pupal epidermis, resulting in a sharp increase in cyclic AMP. The latter acts as a messenger in the induction of the specific response. In this respect, juvenile hormone acts as an antagonist of ecdysone, probably by suppressing the genetic information connected with metamorphosis. 

XLIII Tebufenozid I Antagonist of the insect hormone ecdyson >5000(R)... 

In Table 29.15 we provide structures of J.H. agonists and antagonists and of a substance with some ecdysone-like agonistic properties. 

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