Easily Recyclable Ru Catalysts for Combinatorial Synthesis

The need for multiple weighing measurements to deliver appropriate catalyst loadings to individual reaction mixtures  

The filtration step required to isolate the catalyst for reuse and 

The variable swelling of the polymer supports in different solvents which can lead to unpredictable changes in reaction volume and even cause well overflow. 

For this study, a commercially available (Geltech) glass monolith (6 mm in diameter and 3 mm thick) was selected with an average pore size of 200 A. The virtues of the resulting recyclable catalysts (73-75) stem directly from our choice of solid support  

These highly porous glasses retain a rigid and exposed interfacial surface area (typically 300-1000 m g ), whereas conventional organic polymer beads swell and shrink in different solvents, often with unpredictable effects on catalysis Functionalization of a monolithic (largest dimension 1 mm) gel affords a bulk catalyst sample. This obviates the need for filtration to recover the catalyst tweezers can be used instead  

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Easily Recyclable Ru Catalysts for Combinatorial Synthesis 489 Tab. 11.11 Cross metathesis with eiectron-deficient oiefins cataiyzed by (67) and (69). 

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