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Early Relay Metathesis Discoveries

Hoveyda-Grubbs initiator [Ru]-III nicely solved this problem, presumably because ruthenium loading adjacent to the oxirane was now viable via the relay of 21 to 22. This constituted the first report of a successful application of an RRCM reaction in the context of a natural product total synthesis. [Pg.265]

In a model study of a potential application of RRCM for formation of the C4-C5-trisubstituted alkene in oocydin A (33), the substrates 30a and 30b were each successfully cyclized to the 13-membered lactones 32a and 32b, respectively [Pg.265]

See other pages where Early Relay Metathesis Discoveries is mentioned: [Pg.263]    [Pg.265]    [Pg.267]    [Pg.263]    [Pg.265]    [Pg.267]   


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Metathesis, relay

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