Early Patterning Mechanisms of the Mesoderm

As described in chapters 2 and 3, the primordia of the different mesodermal tissues arise at precisely defined positions within the mesodermal layer. In large part, this is believed to be a result of the spatially restricted activation (or repression) of control genes that determine (or suppress) the formation of particular tissues in a cell-autonomous fashion. Each primordium or field of precursors of a particular tissue is defined by its position along the dorsoventral axis and anteroposterior axis. Classi- 

The Roles of Dpp and Its Downstream Effectors in Dorsal Mesoderm Induction 

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