E. coronaria

Two new alkaloids, ervatinine and stapfinine, have been extracted from the leaves of E. coronaria, a species endemic in Pakistan, which is used in the indigenous system of medicine for the treatment of ophthalmia, in the treatment of wounds, and as an anthelmintic. The structures of both alkaloids were deduced from their mass and nuclear magnetic resonance (NMR) spectra. Ervatinine (16) is an ll-hydroxy-5-oxovoaphylline of unknown stereochemistry (47), and stapfinine (17a) appears to have the relative stereochemistry of 5-hydroxyvoaphylline. Again, the configuration of the hydroxyl group is unknown (48). 

The remaining alkaloid in this group, hyderabadine, is similarly oxidized at positions 14 and 15, and also at C-18. It occurs in the leaves of E. coronaria (52) and is formulated as the pentacyclic ether 21 of undetermined stereochemistry, on the basis of its NMR and mass spectra. 

Pig. 130.—A, B, Lachnea scutelata. A, Habit B, ascus with paraphysis C, D, Lachnea hemisphoerica C, habit D, ascus with paraphysis E, Sarcosphtera aren osa habit F, G, Sarcosphosra coronaria P, ascus G, habit H Sarcosphcera arent cola ascus with paraphysis. See Die naturlichen Pflanzenfamilien I, 1, p. 181.) (Harshberger.)... 

Tabernaemontana dichotoma (L.) R. Br. ex Roem et Schult. (syn Ervatamia coronaria, E. divaricata, Tabernaemontana coronaria, Rejoua dichotoma) [Apocynaceae]... 

Fungi cover a wide range of arsenic concentrations (2000 fg/g), and they contain a most interesting array of arsenic compounds. They are the only organisms containing methylarsonate at appreciable levels, and some species (e.g., Sarcosphaera coronaria) contain >50% of the total extractable arsenic as this... 

N7 Nemesahsky, E., Pavlik, G. and Szelenyi, I. Experimentelle Untersuchungen zur Beeinflussung der Hamodynamik der Arteria coronaria und der Arteria femoralis durch Magne-sium-Orotat-Glycinat. Arzneim. Forsch., 21, 791-794 (1971)... 

Joshi, A. B. Satyanarayana, D. Chandrashekar, K. S. Subrahmanyam, E. V. S. Isolation and characterization of indole alkaloids from the flowers of Ervatamia coronaria (Syn Taberaemontana divari-cata). Nat. Prod. Sci. 2004,10, 96-98. 

Claes E. Estudio mecanico de las arterias coronarias humanas y sus sustitutos vasculares, tesis doctoral, Escuela tecnica superior de ingenieros de caminos, canales y puertos. Universidad Politecnica de Madrid 2010. 

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