Dysrythmias

Halofantrine is usually well tolerated. Gastrointestinal complaints as well as pruritus and skin rashes may occur. It can prolong the QTc interval which can result in ventricular dysrythmias. Lume-fantrine has many similarities to halofantrine but seems not to prolong QTc. It is thus far only used in a fixed dose combination with artemether (see Section VI.a.2.5). 

Mild to moderate sympathomimetic-like mydriatic as well as cardiostimulant viz., rate, force of eontraetion and dysrythmias) activity,... 

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