Dyskinesias, drug-induced therapy

Muscle spasms, particularly those associated with multiple sclerosis or dystonia, may improve significantly with cannabinoid therapy. However, while CBD has been found effective in combination with standard therapy (which was insufficient to adequately control dystonic motor symptoms without CBD), both A -THC and marijuana were found to have untoward side-effects at the doses required to reduce muscle tone. Additionally, CBD may prove beneficial for other hyperkinetic movement disorders such as drug-induced dystonia and possibly tardive dyskinesia. 

Amantadine has also been used for the treatment of PD-related dementia (Greulich and Fenger, 1995). Amantadine has been reported to reduce the duration of levodopa-induced dyskinesia and improves motor disability in PD. Although some beneficial effects are noted in patients after amantadine treatment, this drug is known to induce corneal edema that begins few months to several years after institutional therapy (Jeng et al., 2008). 

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