Dynemicin Effect

The special fascination of strained cyclic enediynes lies in their intrinsic tendency to undergo thermal cyclisation. This aspect has been stimulating the research activities on enediynes since their beginnings more than 20 years ago, [1] and it is this reactivity of the enediyne structure that brings about the pharmacological effectiveness of natural products, like Dynemicin A. [2]... 

Once the structures of the first natural enediyne antibiotics had been elucidated, the scientific community was quick to respond. The mechanisms by which these molecules exert their effects continue to be probed ever deeper, with surprising new details still emerging. The hitherto unprecedented and structurally complex molecular architecture of the natural products has required the development of new synthetic methodology in order to synthesize functional models which would shed new light upon the natural enediyne antibiotics. Researchers in the field have pushed the art of organic synthesis to its present limits with total syntheses of calicheamicin yj (2), the most prominent member of the natural enediyne antibiotics, and a derivative of dynemicin A (4) having been achieved. Furthermore, the factors affecting the... 

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