Dynamic mechanical analysis pharmaceutical applications

Many processes in pharmaceutics are related to transport, and the appHcations of the outlined theory are therefore numerous. Notwithstanding their practical importance, the special instances of the general transport equation (11) listed in Table 2 are assumed to be relatively familiar, and will therefore not be discussed further in this chapter. Instead, we focus our attention on applications of hereditary integrals and linear response theory, in particular on dynamic mechanical analysis (DMA) and impedance spectroscopy. 

Whereas there have been several applications of dynamic mechanical analysis for the characterization of the viscoelastic and mechanical properties of biomedical polymers, the characterization of pharmaceutical polymers has not received similar attention. One possible reason for this disparity has been the relative unavailability of appropriate sample geometries for pharmaceutical systems. However, the availability of newer geometries should address this problem. In spite of these difficulties, several studies have successfully employed dynamic mechanical analysis for the characterization of pharmaceutical systems and some of these are described in the following paragraph. 

The book opens with the first three chapters devoted to differential scanning calorimetry (DSC), the most commonly used thermal method. These chapters cover the principles, optimal use, and pharmaceutical applications of the method. Subsequent chapters explore modulated temperature DSC, thermogravimetric analysis, thermal microscopy, microcalorimetry, high sensitivity DSC, dynamic mechanical analysis, and thermally stimulated current, all of which have attracted great interest within the pharmaceutical field. Each chapter includes theoretical background, measurement optimization, and pharmaceutical applications. 

Craig, D. Q. M., and Johnson,F. A. (1995). Pharmaceutical applications of dynamic mechanical thermal analysis. Thermochim. Acta Pharmaceut. Therm. Anal. 248, 97-115. 

Craig DQM, Johnson F. Pharmaceutical applications of dynamic mechanical thermal analysis. Thermochimica Acta 1995 248 97-115. 

Oscillatory rheometry and dynamic mechanical thermal analysis, both termed dynamic oscillatory methods, allow for the convenient, accurate, and rapid quantification of the viscoelastic properties of pharmaceutical and biomedical systems. In light of this, considerations of the theory, practice, and applications of these methods will form the basis of this chapter. 

Jones S. David, Tian Yiwei, Abu-Diak Osama, and Andrews P. Gawin. Pharmaceutical applications of dynamic mechanical thermal analysis. Adv. Drug Deliv. Rev. 64 no. 5 (2012) 383-478. 

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