Dynamic lineshape analysis, significance

Another example of the application of lineshape analysis to ligand dynamics is described in Section 4.3 for the drug trimetrexate, which binds to dihydrofolate reductase (DHFR). From that example it is clear that the techniques described above can equally be applied to ligands when bound to their receptors. In some cases significant but highly specific mobility appears to be present at the bound site. 

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