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Dynamic Kinetic Resolution and Deracemization

Dynamic kinetic resolution of a-alkyl-P-keto ester was conducted successfully using biocatalysts. For example, baker s yeast gave selectively syn(2R, 3S)-product [29a] and the selectivity was enhanced by using selective inhibitor [29b] or heat treatment of the yeast [29c]. Organic solvent was used for stereochemical control of G. candidum [29d]. Plant cell cultures were used for reduction of 2-methyl-3-oxobu-tanoate and afforded antialcohol with Marchantia [29e,f] and syn-isomer with Glycine max [29f]. [Pg.221]

Extensive screening methodology was used to find the suitable microorganism. As a result, K. pneumoniae IFO 3319 out of 450 bacterial strains was found to give the corresponding (2J, 3S)-hydroxy ester with 99% de and 99% ee in kilogram scale quantitatively [29g]. [Pg.221]

P Diketones can also be reduced diastereoselectively. Thus, a recombinant alcohol dehydrogenase from I. brevis (recLBADH) overexpressed in E. coli was used for [Pg.221]

Other biocatalysts were also used to perform the dynamic kinetic resolution through reduction. For example, Thermoanaerobium brockii reduced the aldehyde with a moderate enantioselectivity [30b,c], and Candida humicola was found, as a result of screening from 107 microorganisms, to give the (Jl)-alcohol with 98.2% ee when ester group was methyl [30dj. [Pg.223]


Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions... [Pg.123]


See other pages where Dynamic Kinetic Resolution and Deracemization is mentioned: [Pg.221]    [Pg.196]    [Pg.720]   


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