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DsDNA repair

BRCA1/BRCA2 Hereditary breast cancer Repair of dsDNA breaks Breast, ovarian... [Pg.583]

Figure 13.11 Reaction sequence of the base excision repair pathway. The base excision repair (BER) pathway is exemplified for the uracil excision-repair reactions. Only the lesioned (e.g. uracil) part of one strand nucleotide structure of the dsDNA is shown. The excision of uracil by uracil DNA glycosylase without associated AP-lyase generally follows AP-endonuclease and 5 -deoxyribophosphodiesterase which cleave the nucleotide chain. The repair with N-glycosylase is associated with AP-lyase (P-elimination reaction catalyzed by AP-lyase converts the deoxyribose residue to aldehyde form) and 3 -phosphodiesterase. The single nucleotide gap is filled by DNA polymerase (dCTP is required to replace uracil) and DNA ligase... Figure 13.11 Reaction sequence of the base excision repair pathway. The base excision repair (BER) pathway is exemplified for the uracil excision-repair reactions. Only the lesioned (e.g. uracil) part of one strand nucleotide structure of the dsDNA is shown. The excision of uracil by uracil DNA glycosylase without associated AP-lyase generally follows AP-endonuclease and 5 -deoxyribophosphodiesterase which cleave the nucleotide chain. The repair with N-glycosylase is associated with AP-lyase (P-elimination reaction catalyzed by AP-lyase converts the deoxyribose residue to aldehyde form) and 3 -phosphodiesterase. The single nucleotide gap is filled by DNA polymerase (dCTP is required to replace uracil) and DNA ligase...
See other pages where DsDNA repair is mentioned: [Pg.196]    [Pg.196]    [Pg.47]    [Pg.55]    [Pg.1549]    [Pg.1566]    [Pg.419]    [Pg.76]    [Pg.345]    [Pg.359]    [Pg.359]    [Pg.470]    [Pg.768]    [Pg.1395]    [Pg.1396]    [Pg.260]    [Pg.636]    [Pg.653]    [Pg.615]    [Pg.632]    [Pg.1123]    [Pg.312]    [Pg.241]    [Pg.177]    [Pg.261]    [Pg.264]    [Pg.53]    [Pg.114]    [Pg.120]    [Pg.194]    [Pg.195]    [Pg.196]    [Pg.197]    [Pg.212]    [Pg.242]    [Pg.252]    [Pg.253]    [Pg.264]    [Pg.309]    [Pg.398]    [Pg.398]    [Pg.425]    [Pg.464]    [Pg.480]    [Pg.553]    [Pg.555]    [Pg.588]    [Pg.640]    [Pg.67]    [Pg.426]   
See also in sourсe #XX -- [ Pg.195 , Pg.196 ]



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