Drugs microparticle biodegradation rates

The size polydispersion, and the very small yield in the micron size range suitable for drug delivery applications, constitutes a significant drawback of this technique. Size uniformity is important for shared biodegradation rates, which depend on both size and porosity. Another drawback of this technique is the shape polydispersion, which affects both the cellular uptake of pSi particles and blood flow characteristics [24]. Microparticle uptake by the reticuloendothelial system (RES), as well as margination and adhesion dynamics in the bloodstream, are strongly correlated to both the shape and size of the particles [21, 25, 26). 

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