Drug Surveys and Screening Procedures

Extremely valuable in this regard are those papers dealing with a large number of pharmaceutical compounds and their retention behavior in methanolic mobile phases. Over 300 compounds were used in a systematic HPLC toxicological survey [488]. A 30°C C,g column (photodiode arnqr detector, A= 190-800 nm with the peak maxima tabulated for each compound) and an isocratic 65/5/30 methanol/THF/water (10 mM phosphate buffer at pH 2.6) mobile phase were used. Blood or plasma samples were extracted and the resulting residue was analyzed. 

The evaluation of the retention of 18 imidazol(in)e derivative drugs was done on an alumina-based C g column, and two silica based C g columns (A = 254 nm) 

Koves [492] developed a rapid screening method for barbiturates, benzodiaza-pines, phenytoin, salicylic acid, acetaminophen, apd theophylline. An isocratic (SO/SO or 40/60) methanol/water mobile phase in conjunction with a C g column ( = 229 nm and photodiode arrjQr detector, X = 210-367 nm) proved particularly effective for this purpose. 

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PHARMACEUTICAL ANALYTES 9.7.1 Drug Surveys and Screening Procedures... 

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