Drug supported diffusion

Here, Pe takes into account the aqueous boundary layers (/W), transcellular diffusion with metabolism, the paracellular pathway (Pparaceu), and the filter support (PF). It is assumed that drug diffusing through the paracellular route escapes metabolism and contributes insignificantly to the appearance of intact drug in the receiver. 

The simplest answer is ease of administration. More importantly, there are several limitations to local delivery of drugs in the form of DES. The efficacy of these new devices depends on several variables, including the selection of an effective drug, its solubility, diffusion characteristics, release kinetics, arterial tissue concentration, retention, and whether the platform is polymer based or nonpolymeric. Local delivery of the drug in this manner may delay rather than prevent neointima. This is supported by preclinical studies that show impaired healing and neointimal catch-up (4). There is concern that neointimal growth will accelerate in response to the... 

In general, the extraction process must be streamlined to reduce solvent consumption since removal of solvents can represent a major bottleneck. Additionally, the extraction method chosen should support the first step of fractionation for library generation. Supercritical fluid extraction (SFE) represents an efficient extraction method in terms of low solvent consumption and extraction speed. Supercritical fluids exhibit high diffusivity with low viscosity and low surface tension they can readily permeate biomass matrices and solvate molecules, including drug-like compounds, leading to efficient extractions. The addition of small amounts of organic co-solvents may enhance... 

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