Drug shape

Different drug qualities were used during the studies to investigate the impact of drug shape on the DPI performance. The drug preparation is described in the following sections. 

Two different studies were performed to analyse the aerodynamic characteristics of the mannitol carrier particles. The first was focussing on the particle-particle interactions between carrier particles dried with the early experimental setup and micronised SBS particles. The second was dealing with carrier particles prepared with the improved experimental setup and spray dried SBS to further discover the effect of drug shape. The five mannitol batches chosen for the blending with micronised SBS were named according to the applied outlet temperature (M67, 80, 84, 92 and 102). The resulting FPF was then discussed to the related particle properties with special focus on particle shape and surface roughness as described in Sects. 3.6.1 and 3.6.2. Table 14.9 shows the particle properties of Mannitol 1-6, which are the six mannitol batches chosen for the second study, and the particle size and shape of the two SBS qualities [11]. 

The neutral glasses are generally less resistant than the hard borosilicate type, but are more easily melted and shaped. They are formulated so that the pH of aqueous solutions is unaffected by contact with the glass, making it particularly suitable in pharmaceutical use for the storage of pH-sensitive drugs. 

With the development of the polymer field in medicine, great attention has been paid to particulate forms of drugs [82], The most widespread methods for the preparation of particulate drugs are microencapsulation and microgranulation, i.e., the inclusion of BAS into spherical shapes of predetermined dimensions. One form of particulate drugs is microcapsules or artificial cells as they were called by... 

Check prescriptions carefully when obtaining refills from die pharmacy and report any changes in die prescription (eg, changes in color, size, shape) to the pharmacist or primary health care provider before taking die drug because an error may have occurred. 

If the patient or caregiver has a problem with drug names, refer to the drug by shape or color. Another idea is to number bottles and use this number on the drug chart. 

Many complexes and coordination compounds exist as isomers, compounds that contain the same numbers of the same atoms but in different arrangements. For example, the ions shown in (13a) and (13b) differ only in the positions of the Cl ligands, but they are distinct species, because they have different physical and chemical properties. Isomerism is of more than academic interest for example, anticancer drugs based on complexes of platinum are active only if they are the correct isomer. The complex needs to have a particular shape to interact with DNA molecules. 

Changes to the size or shape of a container for a non-sterile drug... 

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