Drug release pore volume

The physical properties of pellets have been widely used to determine an acceptable yield of pellets. These include shape indices, size and size distribution, densities, pore volume and distribution, flow properties, and friability. Of course, drug release from the pellets is a critical parameter to be monitored in order to ensure potency and uniformity of drug distribution. 

The drug loading capacity and drug release kinetics are affected by several factors such as the adsorptive properties of the mesoporous materials (e.g., pore size, surface area, pore volume) [35, 36, 52, 55], surface functionalization of the mesoporous materials [37b, 51b, 56, 57], and the drug loading procedures used (e.g., covalent attachment, physical trapping, and adsorption) [58]. These will be discussed individually below. 

Factors such as the size of the crystals within the polymer, pore size and pore volume within the implant, and the overall shape and size of the implant affect the mode of degradation within polymers, and these factors can thus be used to control the release profile in drug delivery applications." ... 

The relevance of the pore structure on the drug release rate from porous matrices is shown in table 2 and figure 2m For a wettable polymer such as the acrylic, the reduction in total pore volume caused by any process,... 

---