Drug release mucoadhesive devices

Due to the turnover of the mucus gel layer of the mucus surface, which in some tissues such as the intestine is very fast, the adhesion of mucoadhesive devices of drug release is more difficult. This fact, along with the non-specificity of adhesion of these devices has caused this to be researched in the development of release systems that include lectins and lectin-like molecules, which can directly interact with the cellular membrane in such a way that a cytoadhesion independent of mucus turnover is produced. ... 

Alternative applications of tablets as oral mucosal devices include, for example, the addition of the active in microspheres prior to compression and use of matrices that melt at body temperatures. " Giunchedi et al. have reported on the use of a spray drying technique to produce chito-san and drug-loaded microspheres to improve the flowability of chitosan and to further enhance the control over drug release. Poloxamer 407 has been reported to improve the mucoadhesion... 

Remunan-Lopez C, Portero A, Vila-Jato JL, Alonso MJ. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. / Control Release 1998 55 143-152. 

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