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Drug release ionic groups

Ion exchange can be an effective method for the controlled release of ionizable drugs that are coupled with the oppositely charged ionic groups on a polymer matrix, as in ion-exchange resins used in gastrointestinal (Gl) applications. The drug release from such a system depends on the ionic environment, that is, pH and electrolyte concentration within the Gl tract, as well as the properties of the resin (5). [Pg.269]

Chitosan molecular weight has also been reported to influence drug release. Jiang et al. [94] studied Bordetella bronchiseptica dermonecrotoxin (BBD) release from chitosan microspheres prepared by tripolyphosphate ionic gelation. It has been shown that the BBD release rate increased with chitosan molecular weight decrease. It has been explained by the weaker BBD interaction with chitosan of lower molecular weight and lower content of free amine groups, responsible for their interaction. [Pg.661]

Ion-Exchange Systems. The ion-exchange systems are useful in the controlled release of ionic (or ionizable) drugs. Polyelectrolytes are crosslinked to form water-insoluble ion-exchange resins. The drug is bound to the ionic groups by salt... [Pg.9]

E. Fenyvesi, A. Ujhazy, J. Szejth, S. Putter, and T.G. Gan, Controlled release of drugs from CD polymers substituted with ionic groups, / Incl Phenom. Macrocycl Chem., 25,185-189,... [Pg.435]

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See also in sourсe #XX -- [ Pg.206 ]



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