Drug property improvement side-effects, reduction

In spite of these problems, the QSAR shown in Figure 2 was of great importance in the search for improved radiosensitizers. Multivariate analysis showed drug lipophilicity was of relatively little importance in mammalian cells in vitro [88], whereas reductions in neurotoxic side-effects were achieved in vivo by reducing the lipophilicity (and the drugs capacities to cross the blood/brain or other lipophilic barriers) [95]. Equally importantly, the pulse radiolysis measurements of reduction potential were applied to data for the cytotoxicity of the radiosensitizers in vitro, in the presence [96] or absence [97] of oxygen, and quantitatively similar relationships between effect and redox property were demonstrated as had been derived for radiosensitization. This pointed to the... 

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