Drug microsomal metabolizing system

Lipid-soluble xenobiotics are commonly biotra ns formed by oxidation in the drug-metabolizing microsomal system (DMMS). For each description below, choose the component of the microsomal mixed-function oxidase system with which it is most closely associated ... 

DMMS—drug-metabolizing microsomal system DNA—deoxyribonucleic acid dopa/DOPA/Dopa—(3,4-dlhydroxyphenylalanine)... 

Bend, J. R., Pohl, R. J., and Fouts, J. R. Some properties of the microsomal drug-metabolizing enzyme system in the little skate, Rada evinaoea. Bull. Mt. Desert Island Biol. Lab. (1972) 12 9-12. 

Mitotane, being closely related to the organochlo-rine insecticides, shares its inductive effects on the fiver microsomal drug-metabolizing enzyme system, and its use may therefore alter the requirement for concomitantly administered drugs that are also metabolized by this pathway. 

Metabolic transformation to more water-soluble metabolites is necessary for clearance of sedative-hypnotics from the body. The microsomal drug-metabolizing enzyme systems of the liver are most important in this regard, so elimination half-life of these drugs depends mainly on the rate of their metabolic transformation. 

Orrenius, S., J.L. Ericsson, and L. Ernster (1965). Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study. J. Cell. Biol. 25, 627-639. 

Kato R, Takayanaghi M (1966) Differences among the action of phenobarbital, methylcholanthrene and male sex hormone on microsomal drug-metabolizing enzyme systems of rat liver. Jpn J Pharmacol 16 380-390... 

Lu, A. Y. H., 1976, Liver microsomal drug-metabolizing enzyme system Functional components and their properties, Ted. Proc. 35 2460. 

Among common in vitro metabolizing systems, liver microsomes and liver S9 fractions are used more often in metabolite synthesis than other systems. The majority of drug metabolism is mediated by CYPs [8]. Liver microsomes contain a high concentration of CYPs and other... 

Sladek, N.E. and Mannering, G.J. (1969) Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems. Molecular Pharmacology, 5 (2), 174-185. 

Palamanda, J., Feng, W.W., Lin, C.C. and Nomeir, A.A. (2000) Stimulation of tolbutamide hydroxylation by acetone and acetonitrile in human liver microsomes and in a cytochrome P-450 2C9-reconstituted system. Drug Metabolism and Disposition, 28 (1), 38-43. 

Mannering, G.J. Microsomal enzyme systems which catalyze drug metabolism. In La Du, B.N., Mandel, H.G. and Way, E.L. (Eds.) Fundamentals of Drug Metabolism and Disposition. Baltimore, Williams.(1971). 

Microsomes Can be frozen and used on demand Contains major drug metabolizing enzymes Straighforward to use Limited enzyme complement Closed system so may not be representative of in vivo situation... 

Glende EA. 1972. Carbon tetrachloride-induced protection against carbon tetrachloride toxicity. The role of the liver microsomal drug-metabolizing system. Biochem Pharmacol 21 1697-1702. 

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