Drug-Induced Proarrhythmic Effects in Dogs with Chronic AV Ablation

Drug-Induced Proarrhythmic Effects in Dogs with Chronic AV Ablation 

Male and female dogs 20 kg are used for these studies. In an initial aseptic surgical procedure, a complete 

The evaluation involves determining incidence of arrhythmia or early after depolarizations after drug 

Using an endocardial monophasic action potential recording, the incidence of early after depolarizations can be determined. The catheter (e.g. Franz combination catheter, EPT No. 1650) can be placed through the jugular vein or carotid artery under fluoroscopic guidance. 

Rodriguez LM, Leunissen J, Hoekstra A et at. (1998) Transvenous cold mapping and cryoablation of the AV node in dogs observations of chronic lesions and comparison to those obtained using radiofrequency ablation. J Cardiovasc Electrophysiol 9 1055-1061 

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