Drug hypersensitivity insulin

III. Contraindications. Known hypersensitivity to the drug (less frequent with human insulin). 

A. Do not give protamine to patients with known sensitivity to the drug. Diabetic patients who have used protamine insulin may be at the greatest risk for hypersensitivity reactions. 

The metabolism and action of many other drugs also show genetically determined variations, e.g. parahydroxylation of diphenylhydantoin, insulin antagonism in serum, rigidity and hyperthermia in anaesthesia, response to antidepressive drugs, phenothiazine-induced extrapyramidal disorders, hypersensitivity and resistance to vitamin D therapy and drug reactions in hereditary porphyria. 

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