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DNA-drug interactions

J. A. Hartley, Selectivity in alkylating agent-DNA interactions, in Molecular Aspects of Anticancer Drug-DNA Interactions Vol. 1 (Eds. S. Neidle, M. Waring), CRC Press, Boca Raton, FL, 1993, 1. [Pg.369]

P. Cieplak, S. N. Rao, P. D. J. Grootenhuis, and P. A. Kollman, Free energy calculation on base specificity of drug-DNA interactions Application to daunomycin and acridine intercalation into DNA, Biopol. 29 717 (1990). [Pg.169]

Their direct mutagenicity makes them excellent vehicles for investigating mechanisms of mutagenesis and structural influences upon the mutagenic process and we have utilised many analogues as probes for drug-DNA interactions.46,49,50... [Pg.97]

Thus, the mutagenicities of /V-acyloxy-/V-alkoxyamides may provide an intracellular means of quantifying structural elements of molecules in terms of their ability to target drugs to DNA they can be used as probes for drug-DNA interactions.50... [Pg.109]

The QSAR (4) cannot only highlight structural factors most likely to impact positively or negatively upon their biological activity, it can be used to probe drug-DNA interactions. QSAR (4) has already enabled identification of candidates with reasonable anticancer activity and can direct future synthesis and design to this end. [Pg.116]

THERMODYNAMICS AND CRYSTALLOGRAPHY OF DRUG-DNA INTERACTION IN CHROMATIN AND NUCLEOSOME... [Pg.177]

Haq 1 (2002) Thermodynamics of drug-DNA interactions. Arch Biochem Biophys 403 1-15 Hsiang YH, Hertzberg R, Hecht S, Liu LE (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase 1. J Biol Chem 260(27) 14873—14878 Hurley LH (2002) DNA and its associated processes as targets for cancer therapy. Nat Rev cancer 2 188-200... [Pg.184]

Steighner RJ, Povirk LF (1990) Bleomycin-induced DNA lesions at mutational hot spots imphcations for the mechanism of double-strand cleavage. Proc Natl Acad Sci USA 87(21) 8350-8354 Straney DC, Crothers DM (1987) Effect of drug-DNA interactions upon transcription initiation at the lac promoter. Biochemistry 26(7) 1987-1995... [Pg.187]

Natrajan A, Hecht SM (1994) Bleomycins mechanism of polynucleotide recognition and oxydative degradation. In Neidle S, Waring M (eds) Molecular aspects of anticancer drug-DNA interactions. MacMillan, London, pp 197-242... [Pg.469]

Drug-DNA Interactions in Solution Acridine Mutagen, Anthracycline Antitumor, and Peptide Antibiotic Complexes... [Pg.219]

See other pages where DNA-drug interactions is mentioned: [Pg.363]    [Pg.151]    [Pg.381]    [Pg.156]    [Pg.178]    [Pg.182]    [Pg.221]    [Pg.223]    [Pg.225]    [Pg.227]    [Pg.229]    [Pg.231]    [Pg.235]    [Pg.237]    [Pg.239]    [Pg.241]    [Pg.243]    [Pg.245]    [Pg.247]    [Pg.249]    [Pg.251]    [Pg.253]    [Pg.255]    [Pg.257]    [Pg.259]    [Pg.261]    [Pg.263]    [Pg.265]    [Pg.267]    [Pg.269]    [Pg.271]    [Pg.273]    [Pg.275]    [Pg.277]    [Pg.279]    [Pg.281]    [Pg.283]    [Pg.285]    [Pg.287]    [Pg.289]    [Pg.291]   
See also in sourсe #XX -- [ Pg.354 ]



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DNA interactions

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