Mammary gland, drug distribution

Regional blood flow changes also occur in pregnant women and can affect drug distribution and elimination. Blood flow increases to the uterus, kidneys, skin, and mammary glands, with a compensatory decrease in skeletal muscle blood flow. At full term, blood flow to the uterus represents about 20-25% of cardiac output and renal blood flow is 20% of cardiac output (15). There is increased blood flow to the skin to dissipate the additional heat produced by the fetus (16). Blood... 

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