Drug discovery research paradigm

Figure 1 Change of the synthesis-and-testing paradigm in drug discovery research, (a) Classical situation where compound (from left to right) and data flows (right to left) are balanced, (b) Increase in synthesis and testing capacities increased data and compound flows, (c) Further increase of data flow due to increased profiling activities and introduction of data mining as a tool to extract information and knowledge.

To withstand the threats on the record of pharmaceutical research and development productivity, numerous so-called paradigm changes have been announced over the past 10-15 years, all aimed at resolving major bottlenecks along the value chain of drug discovery [10-12],... 

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