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Drug discovery, marine natural products

II. Targets for Marine Natural Products Drug Discovery.524... [Pg.523]

III. Marine Natural Products as a Source for Drug Discovery.528... [Pg.523]

VI. A Multidisciplinary Approach to Marine Natural Products Drug Discovery.536... [Pg.523]

II. TARGETS FOR MARINE NATURAL PRODUCTS DRUG DISCOVERY... [Pg.524]

Also at issue is the preservation of marine biodiversity that relates, in turn, to chemical diversity. As stated previously, discoveries to date reflect a small percentage of the resources available. Measures must be taken to ensure sustainable use of these resources. Alternative renewable sources need to be identified to supply pharmacological evaluation. Due to the critical nature of this aspect of marine natural products drug discovery, several alternative approaches are discussed in detail. [Pg.531]

No other single phylum has been more productive than that of the marine Porifera in producing leads for drug discovery and molecular tools. The remarkable activity of the cytotoxic compounds 1-19 (Scheme 6.1 Parts 1 and 2) have led to the development of marine natural products and their congeners as leads in numerous anticancer clinical trials. The actin inhibitors 20-26 (Scheme 6.1 Part 3) have led to the use of sponge-derived agents as probes in the study of cellular processes. In addition, a number of unique structures such as 27-31 (Scheme 6.1 Part 4) have potential as leads in the treatment of other persistent maladies such as asthma, pain and malaria. [Pg.179]

See other pages where Drug discovery, marine natural products is mentioned: [Pg.182]    [Pg.182]    [Pg.62]    [Pg.68]    [Pg.74]    [Pg.77]    [Pg.78]    [Pg.78]    [Pg.78]    [Pg.103]    [Pg.7]    [Pg.70]    [Pg.76]    [Pg.82]    [Pg.85]    [Pg.86]    [Pg.86]    [Pg.86]    [Pg.12]    [Pg.13]    [Pg.62]    [Pg.68]    [Pg.74]    [Pg.77]    [Pg.78]    [Pg.78]    [Pg.78]    [Pg.154]    [Pg.171]    [Pg.172]    [Pg.683]    [Pg.524]    [Pg.528]    [Pg.536]    [Pg.542]    [Pg.631]    [Pg.137]    [Pg.370]    [Pg.370]    [Pg.409]   
See also in sourсe #XX -- [ Pg.524 , Pg.536 ]



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Marine natural products

Natural drugs

Natural product discovery

Production/productivity marine

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