Drug Development Group

Schoffski P, Riggert S, Fumoleau P, et al. Phase 1 trial of intravenous Aviscumine (rViscumin) in patients with solid tumors. A study of the European Organization for Research and Treatment of Cancer (EORTC) New Drug Development Group (NDDG). Ann Oncol 2004 15(12) 1816-1824. 

In a typical research and development setting, in the event that a new drug candidate is recognized by the drug-discovery group, then the dissolution rate constant K for that compound under specified hydro-dynamic conditions can be determined from powder dissolution data and practical size analysis by microscopy. 

The development of synthetic methods for the selective introduction of short-chain perfluoroalkyl groups into organic molecules is of interest in drug development [464]. Fluoromodifications often confer unique properties on a molecule, for example in terms of increased metabolic stability and lipophilicity and, as a consequence, the pharmacokinetic profiles are often improved [465]. Burger and coworkers developed a domino process consisting of a SN reaction combined with a Claisen and a Cope rearrangement which allows the transformation of simple fluorinated compounds into more complex molecules with fluoro atoms [466]. Treatment of furan 2-917 with 2-hydroxymethyl thiophene (2-918) in the presence... 

When the crystallography of compounds related by polymorphism is such that nuclei in the two structures are magnetically nonequivalent, it will follow that the resonances of these nuclei will not be equivalent. Since it is normally not difficult to assign organic functional groups to observed resonances, solid state NMR spectra can be used to deduce the nature of polymorphic variations, especially when the polymorphism is conformational in nature. Such information is extremely valuable at the early states of drug development when solved single crystal structures for each polymorph or solvate species may not yet be available. 

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