Drug development candidate drugs

Vennerstrom JL, Arbe-Bames S, Brun R, Charman SA, Chiu FCK, ChoUet J, Dong Y Dom A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Tomas JS, Scheurer C, Scomeaux B, Tang Y, Urwyler H, WittUn S, Charman WN. (2004) Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430 900-904. 

Vennerstrom JL, Arbe-Barnes S, Brim R, etal.. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430 900—904, 2004. 

Tellers et from Merck optimized this catalyst system for the reduction of an a-substituted ketone that was needed as an intermediate for a drug development candidate. They obtained the best result (93 % ee) with ligand (L) in a method using 90psi hydrogen pressure that was suitable for use at large scale (Figure 1.26). 

In terms of the new MAO inhibitors that may become available in the future, it is possible that some new RIMAs may be approved as antidepressants. Moclobemide, available in many countries, is unlikely, for commercial reasons, to become available in the United States. Another promising RIMA, brofaramine, is also unlikely to be developed for any country. However, befloxatone is progressing in clinical trials, and other RIMAs are also potential drug development candidates, including RS-8359, cimoxatone, and toloxatone. 

Lipper RA. How can we optimize selection of drug development candidates from many compounds at the discovery stage Modern Drug Discovery 1999 2 55-60. 

P-Amino acids (2) are now starting to enjoy use of building blocks within drug development candidates. There are a large number of approaches to this class of compounds, but most are amenable only to laboratory-scale synthesis. These methods have been reviewed.83 86... 

The laboratory of the authors has synthesized analogs related to artemisinin (133). Recently, an antimalarial synthetic trioxolane drug development candidate called OZ-277 (N5, also known as RBxlll60) (134) has sparked great interest and has progressed to Phase II clinical trials in India, Thailand, and... 

Drug discovery finding new chemical entities (NCE) for adoption as new drug development candidates. 

Optimizing Pharmacolo cal Profile and Advancing a Preclinical Drug Development Candidate... 

Fig. (2). Pharmacologically sequential fractionation from hozai. If R2 > a > RI, and a = a2y, where a is the activity and y is the yield, fraction A2 is pharmacologically relevant and appropriate for consideration as drug development candidates, A21 and A22-...

Cheeseright, T. (2009) The identification of bioisosteres as drug development candidates. Innovations in Pharmaceutical Technology, 28, 22-26. 

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