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Drug development bone marrow toxicity test

BONE MARROW TOXICITY TESTING DURING DRUG DEVELOPMENT... [Pg.177]

Busulfan is a potent cytotoxic drug. Early in development of the compound, in vivo experiments indicated that busulfan caused severe depression in the bone marrow. The most prevalent acute toxic effects associated with busulfan in animals are severe pancytopenia from bone marrow failure. Associated in vivo experiments show bone marrow aplasia, stromal cell damage, immunosuppression (impaired T-lymph-ocyte function), and pronounced adverse effects on reproductive glands, germ cells, and fertility in animals (lowest effective dose tested was 2 mg kg... [Pg.352]

See other pages where Drug development bone marrow toxicity test is mentioned: [Pg.63]    [Pg.281]    [Pg.177]    [Pg.178]    [Pg.33]    [Pg.28]    [Pg.69]    [Pg.1864]    [Pg.437]    [Pg.226]    [Pg.45]    [Pg.84]   
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