Potency drug design

These relationships have been useful to a certain extent as the basis for rational methods of drug design (24), and have been valuable also as probes for assessing which molecular properties are actually involved in determining drug potency and toxicity (23). ... 

It is possible that QSAR, an empirical correlation of the data, may provide a pharmacophoric model that will be useful in next-generation drug design within this class. In such an approach, it is hoped that many of the factors which define antimalarial potency can be correlated with the structures of the analogues, and the resulting model, if valid, could be used as a predictive tool. 

The word drugability is often used to cover all aspects of a molecule beyond initial potency. A potential drug compound must overcome many challenges in order to be a successful therapeutic. Critical components of drug design include absorption, permeation, distribution, metabolism, stability, specificity (does it do more than... 

Gaining maximum potency is only half the problem in drug design. The other half is to minimize unwanted side effects. Therefore, for the ultimate in maximization of the therapeutic index, regression analysis must also be applied to relate substituent effects to the various kinds of serious toxicity as these become evident. 

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