Tissue-specific drug delivery

Targeting Drug Delivery to Specific Cells and Tissues... 

The first purpose, drug targeting, is defined as selective drug delivery to specific physiological sites—organs, tissues, or cells—where a drug s pharmacological activities are... 

Improved characterization of the morphological/microstructural properties of porous solids, and the associated transport properties of fluids imbibed into these materials, is crucial to the development of new porous materials, such as ceramics. Of particular interest is the fabrication of so-called functionalized ceramics, which contain a pore structure tailored to a specific biomedical or industrial application (e.g., molecular filters, catalysts, gas storage cells, drug delivery devices, tissue scaffolds) [1-3]. Functionalization of ceramics can involve the use of graded or layered pore microstructure, morphology or chemical composition. 

Wacher, V. J., Wu, C. Y., Benet, L. Z., Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein implications for drug delivery and activity in cancer chemotherapy, Mol. Carcinogen. 1995, 13, 129-134. 

Wacher VJ, Wu CY and Benet LZ (1995) Overlapping Substrate Specificities and Tissue Distribution of Cytochrome-P450 3a and P-Glycoprotein—Implications for Drug-Delivery and Activity in Cancer-Chemotherapy. Mol Carcinog 13 pp 129-134. 

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