Drug delivery system with supramolecular assemblies

Drug Delivery Systems With Supramolecular Assemblies.30... 

The drug delivery system based on supramolecular vesicles that were self-assembled by a novel host-guest inclusion complex between a water-solution pillar[6]arene (WP6) and hydrophobic ferrocene derivative in water has been developed. The inclusion complexation between WP6 and ferrocene derivative in water was studied by NMR, UV-vis, and fluorescence spectroscopy, which showed a high binding constant of (1.27 0.42) X 10 with 1 1 binding stoichiometiy. ... 

Host-guest systems made from dendritic materials have potential in the areas of membrane transport and drug delivery [68, 84, 85]. In a recent report [136] Tomalia and coworkers investigated structural aspects of a series of PAM AM bolaamphiphiles (e.g., 50) with a hydrophobic diamino do decane core unit. Fluorescence emission of added dye (nile red) was significantly enhanced in an aqueous medium in the presence of 50 unlike the cases when 51 and 52 were added (Fig. 23). Addition of anion surfactants to this mixture generated supramolecular assemblies which enhanced their ability (ca.by 10-fold) to accommodate nile red (53). Further increase in emission was noted by decreasing the pH from the normal value of 11 for PAMAM dendrimers to 7. At lower pH values the... 

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